For Doctors

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Whole Genome 

Sequencing Technology

 

Sequences data from 23 pairs of chromosomes to detect trisomies,

sex chromosome abnormalities and selected deletions.

SIMPLE: Requires a minimum of 10 ml of maternal blood - paternal blood is not required for the iGene® NIPT test.

 

 

DETECTION OF T21, T18, T13: iGene® NIPT can detect Down Syndrome (T21), Edward Syndrome (T18) and Patau Syndrome (T13)[1].

 

 

TURNAROUND TIME: Turnaround time for results is between 7 to 10 working days upon receipt of the blood sample in the laboratory.

iGene® NIPT is powered by BGI Technology

iGene® NIPT is powered by BGI Technology

Accredited Laboratory

iGene
® NIPT is tested at iGene Laboratory, a molecular diagnostics laboratory in Singapore, accredited by the College of American Pathologists (CAP) and licensed by the Ministry of Health (Singapore) as a Clinical Laboratory (License Number: 17I0382/02/192).

Quality Standards

iGene Laboratory participates in proficiency testing under the international External Quality Assessments (EQA) from CAP and GenQA (formerly known as UK NEQAS), to ensure reliable results. 

Ordering iGene® NIPT

1

Complete Request Form

Please go through the iGene® NIPT Consent Form with your patient and complete the iGene® NIPT Request & Consent Form. Pre-test and Post-test counselling is recommended. 

2

Collect Blood Sample

Draw a minimum of 10 ml of patient's blood (21G needle recommended) into a Streck Tube vacutainer, then place the Streck Tube into the biohazard bag and send it to iGene Laboratory. Turnaround time for sample processing is between 7 to 10 working days from receipt of sample in the laboratory.

 

Note: Do not chill the Streck Tube.

3

Receive Report

When you receive your patient’s report, it is reported as “Screen Negative” or “Screen Positive”.

 

If the result is “Screen Positive”, it is recommended that your patient undergo further confirmatory by diagnostics testing such as amniocentesis, which is an invasive test[2]. This is because iGene® NIPT is a screening and not a diagnostic test.

iGene® NIPT is powered by BGI Technology

Frequently Asked Questions (FAQs)

If my patient tests Screen Negative for iGene® NIPT, what can I tell my patient?


A screen negative result suggests low risk for the tested aneuploidies.




How do I order iGene® NIPT?


Please contact Toll Free Careline at 800-130-1505 or send an email to contact@igenelab.com and a representative will contact you.




When is the earliest gestation that the iGene® NIPT test can be done?


iGene® NIPT can be done from 10 weeks of gestation.




What is the turnaround time for the iGene® NIPT results?


The turnaround time of iGene® NIPT is approximately 7 to 10 working days from receipt of the blood sample in the laboratory.




Do we need informed consent?


Yes. It is generally regarded that all pregnant women should be made aware of all available screening tests for fetal aneuploidies. Informed choice will determine which pregnant women would choose which test, if any. Patients need to sign an iGene® NIPT Request & Consent Form, which explains the detection rate and limitations of the test.




If my patient tests Screen Positive for iGene® NIPT, what happens next?


NIPT is a screening test and not a diagnostic. Therefore, a SCREEN POSITIVE result requires confirmation by amniocentesis and karyotyping. Source: Gregg, A. R., et al. (2016). Noninvasive prenatal screening for fetal aneuploidy, 2016 update: A position statement of the American College of Medical Genetics and Genomics. Genetics in Medicine.





Reference:

1. Zhang H, et al. (2015) Ultrasound Obstet. & Gynecol. 10.1002/uog/14792.

2. Gregg, A. R., et al. (2016). Noninvasive prenatal screening for fetal aneuploidy, 2016 update: A position statement of the American College of Medical Genetics and Genomics. Genetics in Medicine. doi:10.1038/gim.2016.97

 

iGene® NIPT is powered by BGI Technology

iGene® NIPT is tested at iGene Laboratory Pte Ltd, a wholly owned subsidiary of INEX Innovate Private Limited,

iGene Laboratory is licensed by the Ministry of Health of Singapore as a Clinical Laboratory

(License Number: 17I0382/02/192) to provide services in Molecular Pathology (Non-Invasive Prenatal Testing).

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© 2020 iGene Laboratory Pte Ltd
Last updated: Feb 2020